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Most of presently developed condepts and theories on regional development suggest that one of most important determinants of lasting and harmonious regional development is cooperation between entities belonging to the following threespheres - business, science and government ( triple helix). This specific kind of cooperation nderstood as network connections occurring inside the triple helix transfoem participating enterprises, organization and institutions from relatively independent entities into inter-dependent spheres.Howeyer, intensity of cooperation in region depends on a variety of different factors, both internal and external, including cultural,social, ethical, geographical and hisorical conditions. This abundance of determinants of regional development causes that working out a universal model of management and development of the triple helix relations is an extremely demanding challenge. Thus paper is anattempt to define the role of a leader in the process of management of interorganization networks in a region.This work was developed within the framework of research project funded by the Ministry of Science and Higher Education 'The Application of the Triple Helix Model in Management of Innovation policy in metropplises (Project Ref.No 1703/b/H03/2010/38).
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