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Our study aimed to verify the hypothesis of the existence of a programming effect ofparental obesity on the growth, development and mineralization of the skeletal system in female andmale rat offspring on the day of weaning. The study began with the induction of obesity in femaleand male rats of the parental generation, using a high-energy diet (group F). Females and males of thecontrol group received the standard diet (group S). After 90 days of dietary-induced obesity, the dietin group F was changed into the standard. Rats from groups F and S were mated to obtain offspringwhich stayed with their mothers until 21 days of age. Tibia was tested using dual-energy X-rayabsorptiometry (DXA), peripheral quantitative computed tomography (pQCT), micro-computedtomography (μCT) and mechanical strength using the three-point bending test. Biochemical analysisof blood serum bone metabolism markers was performed. DXA analysis showed higher tibia bonemineral content (BMC) and area. pQCT measurements of cortical and trabecular tissue documentedthe increase of the volumetric bone mineral density and BMC of both bone compartments in offspringfrom the F group, whileμCT of the trabecular tissue showed an increase in trabecular thicknessand a decrease of its separation. Parental obesity, hence, exerts a programming influence on thedevelopment of the skeletal system of the offspring on the day of the weaning, which was reflectedin the intensification of mineralization and increased bone strength.
