Degradation of selected cytostatic medicines in hospital wastewater by ozonation
Fragment książki (Rozdział w monografii)
MNiSW
50
Poziom II
| Status: | |
| Autorzy: | Czerwiński Jacek, Skupiński Sebastian |
| Dyscypliny: | |
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| Wersja dokumentu: | Drukowana | Elektroniczna |
| Język: | angielski |
| Strony: | 137 - 144 |
| Efekt badań statutowych | NIE |
| Materiał konferencyjny: | NIE |
| Publikacja OA: | NIE |
| Abstrakty: | angielski |
| In recent years, a significant increase in the application of chemotherapeutic drugs is observed, along with their appearance in the environment. For many years, there were no standards regulating the limitations on the introduction of medicines to the environment. Significant amounts of these pollutants were discharged with municipal wastewater to the treatment plants which were not adapted for their removal. It was shown that the standard technologies are characterized by low efficiency in terms of removing the active substances of drugs and their metabolites. Therefore, it is necessary to implement additional steps in the technological system of treatment plants, based on advanced oxidation processes such as ozonation and UV irradiation. Moreover, numerous substances negatively impact the biotechnological processes, inhibiting biochemical reactions and multiplication of utilized microorganisms. Determinations of the analyzed cytostatics were carried out with the HPLC-MS/MS method, using Agilent 1200 series HPLC and Q-trap 4000 MS/MS system. The results showed that cyclophosphamide was present in hospital wastewater in the range 98–841 ng·L−1, while iphosphamide was present in some months in the effluents from only one wastewater treatment plant and hospital effluents in the range 45–622 ng·L−1. Degradation of the analyzed cytostatics ranged from ~80 till ca.100%. |
