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Status:
Warianty tytułu:	Highly Porous Fluorapatite/beta-1,3-Glucan Composite for Bone Tissue Regeneration: Characterization and In-Vitro Assessment of Biomedical Potential
Autorzy:	Borkowski Leszek, Przekora Agata, Belcarz Anna, Pałka Krzysztof, Jojczuk Mariusz, Łukasiewicz Piotr, Nogalski Adam, Ginalska Grażyna
Dyscypliny:
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Rok wydania:	2021
Wersja dokumentu:	Drukowana \| Elektroniczna
Język:	angielski
Numer czasopisma:	19
Wolumen/Tom:	22
Numer artykułu:	10414
Strony:	1 - 20
Impact Factor:	6,208
Web of Science® Times Cited:	16
Scopus® Cytowania:	16
Bazy:	Web of Science \| Scopus
Efekt badań statutowych	NIE
Finansowanie:	This research was funded by the Ministry of Science and Higher Education in Poland within two projects of the Medical University of Lublin (DS2 and DS117) and by the Medical University of Lublin within Young Scientists Program awarded to Leszek Borkowski (MNmb3). The authors would also like to acknowledge the research funding within statutory activity of Lublin University of Technology (M/KIM/FN25/2021).
Materiał konferencyjny:	NIE
Publikacja OA:	TAK
Licencja:
Sposób udostępnienia:	Witryna wydawcy
Wersja tekstu:	Ostateczna wersja opublikowana
Czas opublikowania:	W momencie opublikowania
Data opublikowania w OA:	27 września 2021
Abstrakty:	angielski
	A novel fluorapatite/glucan composite (“FAP/glucan”) was developed for the treatment of bone defects. Due to the presence of polysaccharide polymer (β-1,3-glucan), the composite is highly flexible and thus very convenient for surgery. Its physicochemical and microstructural properties were evaluated using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), mercury intrusion, mechanical testing and compared with the reference material, which was a hydroxyapatite/glucan composite (“HAP/glucan”) with hydroxyapatite granules (HAP) instead of FAP. It was found that FAP/glucan has a higher density and lower porosity than the reference material. The correlation between the Young’s modulus and the compressive strength between the materials is different in a dry and wet state. Bioactivity assessment showed a lower ability to form apatite and lower uptake of apatite-forming ions from the simulated body fluid by FAP/glucan material in comparison to the reference material. Moreover, FAP/glucan was determined to be of optimal fluoride release capacity for osteoblasts growth requirements. The results of cell culture experiments showed that fluoride-containing biomaterial was non-toxic, enhanced the synthesis of osteocalcin and stimulated the adhesion of osteogenic cells.

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Highly Porous Fluorapatite/β-1,3-Glucan Composite for Bone Tissue Regeneration: Characterization and In Vitro Assessment of Biomedical Potential

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