Gold Nanorods for Doxorubicin Delivery: Numerical Analysis of Electric Field Enhancement, Optical Properties and Drug Loading/Releasing Efficiency
Artykuł w czasopiśmie
MNiSW
140
Lista 2021
| Status: | |
| Autorzy: | Qamar Muhammad, Abbas Ghulam, Afzaal Muhammad, Naz Muhammad Y., Ghuffar Abdul, Irfan Muhammad, Legutko Stanisław, Józwik Jerzy, Zawada-Michałowska Magdalena, Ghanim Abdulnour Ali Jazem, Rahman Saifur, Niazi Usama M., Jalalah Mohammed, Alkahtani Fahad Salem, Rahman Saifur, Khan Mohammad Kamal Asif, Kosicka Ewelina |
| Dyscypliny: | |
| Aby zobaczyć szczegóły należy się zalogować. | |
| Rok wydania: | 2022 |
| Wersja dokumentu: | Drukowana | Elektroniczna |
| Język: | angielski |
| Numer czasopisma: | 5 |
| Wolumen/Tom: | 15 |
| Numer artykułu: | 1764 |
| Strony: | 1 - 15 |
| Web of Science® Times Cited: | 11 |
| Scopus® Cytowania: | 11 |
| Bazy: | Web of Science | Scopus |
| Efekt badań statutowych | NIE |
| Finansowanie: | The publication fee of the journal was paid by the framework of the project Lublin Uni- versity of Technology-Regional Excellence Initiative, funded by the Polish Ministry of Science and Higher Education (contract No. 030/RID/2018/19). |
| Materiał konferencyjny: | NIE |
| Publikacja OA: | TAK |
| Licencja: | |
| Sposób udostępnienia: | Witryna wydawcy |
| Wersja tekstu: | Ostateczna wersja opublikowana |
| Czas opublikowania: | W momencie opublikowania |
| Data opublikowania w OA: | 26 lutego 2022 |
| Abstrakty: | angielski |
| The optical properties and electric field enhancement of gold nanorods for different cases were investigated in this study. The numerical analysis was carried out to understand the functionality and working of gold nanorods, while the experimental portion of the work was focused on the efficiency of gold nanorods for targeted drug delivery. COMSOL Multiphysics was used for numerical analysis. The theoretical results suggest the use of gold nanorods (AuNRs) for anticancer applications. The resonance peaks for gold nanorods of 10 nm diameter were observed at 560 nm. The resonance peaks shifted towards longer wavelengths with an increase in nanorod size. The resonance peaks showed a shift of 140 nm with a change in nanorod length from 25 to 45 nm. On the experimental side, 22 nm, 35 nm and 47 nm long gold nanorods were produced using the seed-mediated growth method. The surface morphology of the nanorods, as well as their optical characteristics, were characterized. Later, gold nanorods were applied to the targeted delivery of the doxorubicin drug. Gold nanorods showed better efficiency for doxorubicin drug loading time, release time, loading temperature, and release temperature. These results reveal that AuNRs@DA possess good ability to load and deliver the drug directly to the tumorous cells since these cells show high temperature and acidity. |
