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The paper presents the results of experimental strength tests of specimens made of two
commercially available bone cements subjected to compression, that is a typical variant of load of
this material during use in the human body, after it has been used for implantation of prostheses or
supplementation of bone defects. One of the factors analysed in detail was the duration of cement
seasoning in Ringer’s solution that simulates the aggressive environment of the human body and
material degradation caused by it. The study also focused on the parameters of quantitative deviation
from the recommended proportions of liquid (MMA monomer, accelerator and stabiliser) and
powder (PMMA prepolymer and initiator) components, i.e., unintentional inaccuracy of component
proportioning at the stage of cement mass preparation. Statistical analysis has shown the influence
of these factors on the decrease in compressive strength of the cements studied, which may be of
significant importance in operational practice.