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Publikacje Pracowników Politechniki Lubelskiej

Publikacje Pracowników PL z lat 1990-2010

Publikacje pracowników Politechniki Lubelskie z lat 1990-2010 dostępne są jak dotychczas w starej bazie publikacji
LINK DO STAREJ BAZY

MNiSW
140
Lista 2021
Status:
Autorzy: Klimek Katarzyna, Pałka Krzysztof, Truszkiewicz Wiesław, Douglas Timothy E. L., Nurzyńska Aleksandra, Ginalska Grażyna
Dyscypliny:
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Rok wydania: 2022
Wersja dokumentu: Drukowana | Elektroniczna
Język: angielski
Numer czasopisma: 20
Wolumen/Tom: 11
Numer artykułu: 3251
Strony: 1 - 19
Web of Science® Times Cited: 0
Scopus® Cytowania: 0
Bazy: Web of Science | Scopus
Efekt badań statutowych NIE
Finansowanie: This research was funded by National Science Centre (NCN) in Poland in the framework of the MINIATURA 4 grant no. 2020/04/X/ST5/00112 entitled “Influence of protein isolate on biocompatibility improvement of curdlan-based biomaterial”. The paper was developed using the equipment purchased in the framework of the agreement no. POPW.01.03.00-06-010/09-00 Operational Program Development of Eastern Poland 2007–2013, Priority Axis I, Modern Economy, Operations 1.3. Innovations Promotion.
Materiał konferencyjny: NIE
Publikacja OA: TAK
Licencja:
Sposób udostępnienia: Witryna wydawcy
Wersja tekstu: Ostateczna wersja opublikowana
Czas opublikowania: W momencie opublikowania
Data opublikowania w OA: 16 października 2022
Abstrakty: angielski
The number of bone fractures and cracks requiring surgical interventions increases every year; hence, there is a huge need to develop new potential bone scaffolds for bone regeneration. The goal of this study was to gain knowledge about the basic properties of novel curdlan/whey protein isolate/hydroxyapatite biomaterials in the context of their use in bone tissue engineering. The purpose of this research was also to determine whether the concentration of whey protein isolate in scaffolds has an influence on their properties. Thus, two biomaterials differing in the concentration of whey protein isolate (i.e., 25 wt.% and 35 wt.%; hereafter called Cur_WPI25_HAp and Cur_WPI35_HAp, respectively) were fabricated and subjected to evaluation of porosity, mechanical properties, swelling ability, protein release capacity, enzymatic biodegradability, bioactivity, and cytocompatibility towards osteoblasts in vitro. It was found that both biomaterials fulfilled a number of requirements for bone scaffolds, as they demonstrated limited swelling and the ability to undergo controllable enzymatic biodegradation, to form apatite layers on their surfaces and to support the viability, growth, proliferation, and differentiation of osteoblasts. On the other hand, the biomaterials were characterized by low open porosity, which may hinder the penetration of cells though their structure. Moreover, they had low mechanical properties compared to natural bone, which limits their use to filling of bone defects in non-load bearing implantation areas, e.g., in the craniofacial area, but then they will be additionally supported by application of mechanically strong materials such as titanium plates. Thus, this preliminary in vitro research indicates that biomaterials composed of curdlan, whey protein isolate, and hydroxyapatite seem promising for bone tissue engineering applications, but their porosity and mechanical properties should be improved. This will be the subject of our further work.