Baza Publikacji Pracowników Politechniki Lubelskiej

Status:
Autorzy:	Budziak-Wieczorek Iwona, Ślusarczyk Lidia, Myśliwa-Kurdziel Beata, Kurdziel Martyna, Srebro-Hooper Monika, Korona-Głowniak Izabela, Gagoś Mariusz, Gładyszewski Grzegorz, Stepulak Andrzej, Kluczyk Dariusz, Matwijczuk Arkadiusz
Dyscypliny:
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Rok wydania:	2022
Wersja dokumentu:	Drukowana \| Elektroniczna
Język:	angielski
Wolumen/Tom:	12
Numer artykułu:	22140
Strony:	1 - 19
Impact Factor:	4,6
Web of Science® Times Cited:	16
Scopus® Cytowania:	16
Bazy:	Web of Science \| Scopus
Efekt badań statutowych	NIE
Finansowanie:	The Authors acknowledge financial support from the National Science Center of Poland under project No. 2019/35/B/NZ7/02756 and by the Polish Ministry of Science and Higher Education “Young Scientists' Research Grants”, project No. VKCh/MN-1/TŻ/21.
Materiał konferencyjny:	NIE
Publikacja OA:	TAK
Licencja:
Sposób udostępnienia:	Witryna wydawcy
Wersja tekstu:	Ostateczna wersja opublikowana
Czas opublikowania:	W momencie opublikowania
Data opublikowania w OA:	22 grudnia 2022
Abstrakty:	angielski
	In the presented study, advanced experimental techniques, including electronic absorption and fluorescence spectroscopies [with Resonance Light Scattering (RLS)], measurements of fluorescence lifetimes in the frequency domain, calculations of dipole moment fluctuations, quantum yields, and radiative and non-radiative transfer constants, were used to characterize a selected analogue from the group of 1,3,4-thiadiazole, namely: 4-[5-(naphthalen-1-ylmethyl)-1,3,4-thiadiazol-2-yl]benzene-1,3-diol (NTBD), intrinsically capable to demonstrate enol → keto excited-states intramolecular proton transfer (ESIPT) effects. The results of spectroscopic analyses conducted in solvent media as well as selected mixtures were complemented by considering biological properties of the derivative in question, particularly in terms of its potential microbiological activity. The compound demonstrated a dual fluorescence effect in non-polar solvents, e.g. chloroform and DMSO/H2O mixtures, while in polar solvents only a single emission maximum was detected. In the studied systems, ESIPT effects were indeed observed, as was the associated phenomenon of dual fluorescence, and, as demonstrated for the DMSO: H2O mixtures, the same could be relatively easily induced by aggregation effects related to aggregation-induced emission (AIE). Subsequently conducted quantum-chemical (TD-)DFT calculations supported further possibility of ESIPT effects. The following article provides a comprehensive description of the spectroscopic and biological properties of the analyzed 1,3,4-thiadiazole derivatives, highlighting its potential applicability as a very good fluorescence probes as well as a compound capable of high microbiological activity.

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Spectroscopic characterization and assessment of microbiological potential of 1,3,4-thiadiazole derivative showing ESIPT dual fluorescence enhanced by aggregation effects

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