Correlation of phase composition, magnetic properties and hyperthermia efficiency of silica-coated FeCo nanoparticles for therapeutic applications
Artykuł w czasopiśmie
MNiSW
100
Lista 2023
| Status: | |
| Autorzy: | Linh Pham Hoai, Fedotova Julia A., Vorobyova Svetlana, Nguyen Luu Huu, Huong Tran Thi, Nguyen Hong Nhung, Nguyen Thi Ngoc Anh, Hoang Anh Son, Nguyen Quang Anh, Gumiennik Uladzislaw, Konakov Artem, Bushinskij Maxim, Żukowski Paweł, Kołtunowicz Tomasz |
| Dyscypliny: | |
| Aby zobaczyć szczegóły należy się zalogować. | |
| Rok wydania: | 2023 |
| Wersja dokumentu: | Drukowana | Elektroniczna |
| Język: | angielski |
| Wolumen/Tom: | 295 |
| Numer artykułu: | 116571 |
| Strony: | 1 - 11 |
| Web of Science® Times Cited: | 0 |
| Scopus® Cytowania: | 1 |
| Bazy: | Web of Science | Scopus |
| Efekt badań statutowych | NIE |
| Finansowanie: | Financial support of BRFFR-VANT project F21V-008 is gratefully acknowledged. This work was also supported by funding from Viet Nam Academy of Science and Technology with a Grant number QTBY01.05/21-22 and from the Vietnamese Ministry of Science and Technology (MOST) under Project NĐT/BY/22/16. The research was also supported by the subsidy of the Ministry of Education and Science (Poland) for the Lublin University of Technology as funds allocated for scientific activities in the scientific discipline of Automation, Electronics, Electrical Engineering and Space Technologies – grants: FD-20/EE-2/703, FD-20/EE-2/709. |
| Materiał konferencyjny: | NIE |
| Publikacja OA: | TAK |
| Licencja: | |
| Sposób udostępnienia: | Witryna wydawcy |
| Wersja tekstu: | Ostateczna wersja opublikowana |
| Czas opublikowania: | W momencie opublikowania |
| Data opublikowania w OA: | 18 maja 2023 |
| Abstrakty: | angielski |
| The local atomic order, magnetic properties, hyperthermia efficiency, drug loading capacity and in-vitro cytotoxicity are investigated for the core–shell (Fe25Co75)x(SiO2)100-x (70 ≤ x ≤ 100, wt.%) nanoparticles (NPs) sintered by the metals co-precipitation followed with SiO2 TEOS deposition. Electron microscopy reveal the formation of nearly spherical structures with medium diameter from 80 nm to 220 nm containing 20–50 nm cores identified by XRD as α-FeCo bcc alloy. Mössbauer spectra and magnetometry reflects the formation of magnetically-interacting net of single-domain FeCo cores with broad size distribution. Observed decrease in magnetization (MS) and effective magnetic anisotropy (Keff) for NPs with × is the consequence of the increasing thickness of the SiO2 shells. Calculations indicate that there is an optimal thickness δ of SiO2 shells ranging between 90 ÷ 120 nm for the highest value of specific absorption rate (SAR) originating from their effect on Keff values. Experimentally proved that SAR has the highest value for (FeCo)80(SiO2)20 NPs in correlation with the Linear Response Theory approach. High drug loading capacity (up to 98 %) and low in-vitro cytotoxicity (IC50 index below 230 µg/ml) experimentally proved for (FeCo)x(SiO2)100-x NPs make them perfect candidates for designing smart drug delivery systems. |
