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The beginning of the 21st century initiated a discussion in the literature on new manufacturing paradigms referred to as Industry 4.0, which are a consequence of the unprecedented development of information technology, supporting various areas of human activity. In 2021, the European Commission announced assumptions for the concept of Industry 5.0, drawing attention to the special role of humans in manufacturing processes. This article discusses the essence of vertical integration in the implementation of the assumptions of mass personalization, which is the essence of Industry 5.0. As part of the research work, aimed at a systematic review of the literature, it has been shown that the strategy of vertical integration and its strengths can be the basis for building an effective policy in a period of turbulent changes, characteristic of the modern market. A special role was devoted to cobotic systems, which are a key element in the effective implementation of vertical integration.