Examination of physicochemical characteristics of blends of synthetic elastin-mimetic polypentapeptide with chitosan: Inhibitory potential on pancreatic α-amylase
Artykuł w czasopiśmie
MNiSW
70
Lista 2024
| Status: | |
| Autorzy: | Lokesh H. R., Kathyayani D., Mahesh B., Suhas P., Prasad C.S. Mahadeva, Rekha N. D., Sionkowska Alina, Gowda D. Channe, Klepka Tomasz |
| Dyscypliny: | |
| Aby zobaczyć szczegóły należy się zalogować. | |
| Rok wydania: | 2025 |
| Wersja dokumentu: | Drukowana | Elektroniczna |
| Język: | angielski |
| Numer czasopisma: | Pt 1 |
| Wolumen/Tom: | 349 |
| Strony: | 1 - 15 |
| Impact Factor: | 4,7 |
| Web of Science® Times Cited: | 0 |
| Scopus® Cytowania: | 0 |
| Bazy: | Web of Science | Scopus |
| Efekt badań statutowych | NIE |
| Materiał konferencyjny: | NIE |
| Publikacja OA: | NIE |
| Abstrakty: | angielski |
| The elastin-like polypentapeptide, poly(GVGVP), composed of valine (V), glycine (G), and proline (P), has been synthesized and investigated for its physicochemical characteristics in polymeric blends with chitosan. The structural, morphological, and intermolecular interactions between poly(GVGVP) and chitosan in both aqueous and solid phases at room temperature were investigated using viscometry, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The thermal characteristics of the blends, including thermal stability and glass transition temperature (Tg), were assessed using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), individually. The blend combinations exhibited improved thermal stability compared to the distinct polymers. The results indicate strong intermolecular interactions between chitosan and the polypentapeptide in both aqueous and solid phases. Further, in vitro studies of various polypentapeptide–chitosan proportions demonstrated α-amylase inhibition, with IC50 values ranging from 9.1 and 5.8 μg, comparable to that of acarbose. Furthermore, this was verified by kinetic parameters (Km and Vmax) obtained from Michaelis–Menten and Lineweaver–Burk plots. These novel blends demonstrate the potential for expanding biomaterials with promising biomedical applications. |
