Modification of Natural Clays with Magnetite to Provide Boosted Antimicrobial Properties and Chemopreventive Activity Against Melanoma
Artykuł w czasopiśmie
MNiSW
140
Lista 2024
| Status: | |
| Autorzy: | Wójcik Alicja, Matusiak Jakub, Trzaskowska Marta, Maciejczyk Aleksandra, Kazimierczak Paulina, Suśniak Katarzyna, Pałka Krzysztof, Korona-Głowniak Izabela, Franus Wojciech, Przekora Agata |
| Dyscypliny: | |
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| Rok wydania: | 2025 |
| Wersja dokumentu: | Drukowana | Elektroniczna |
| Język: | angielski |
| Numer czasopisma: | 20 |
| Wolumen/Tom: | 18 |
| Numer artykułu: | 4759 |
| Strony: | 1 - 20 |
| Impact Factor: | 3,2 |
| Web of Science® Times Cited: | 0 |
| Scopus® Cytowania: | 0 |
| Bazy: | Web of Science | Scopus |
| Efekt badań statutowych | NIE |
| Materiał konferencyjny: | NIE |
| Publikacja OA: | TAK |
| Licencja: | |
| Sposób udostępnienia: | Witryna wydawcy |
| Wersja tekstu: | Ostateczna wersja opublikowana |
| Czas opublikowania: | W momencie opublikowania |
| Data opublikowania w OA: | 17 października 2025 |
| Abstrakty: | angielski |
| Historically, clays have been widely used for the treatment of wounds and to stop hem- orrhaging. The aim of this study was to combine four natural clay minerals (kaolinite, glauconite, montmorillonite, and bentonite) with magnetite (Fe3O4) nanoparticles to pro- duce Fe3O4–clay complexes with enhanced antimicrobial properties and chemopreventive activity against melanoma. The magnetite–clay complexes were synthesized by the chem- ical co-precipitation method and characterized using XRD, TEM, STEM-EDS, SEM, and SQUID magnetometer. Antimicrobial properties were determined by evaluation of MIC values. The most promising materials were also subjected to direct contact antibacterial test according to the OECD standard for porous materials. Cytotoxicity of the complexes towards melanoma cells and normal human skin fibroblasts was assessed by MTT assay. We performed XRD, which confirmed the formation of Fe3O4–clay complex materials. It was also proven that complexes exhibited superparamagnetic properties. Microbiological experiments clearly revealed that modification of natural clays with magnetite signifi- cantly boosted their antimicrobial properties. Fe3O4–montmorillonite and Fe3O4–bentonite showed the strongest antimicrobial activity. Moreover, the mentioned complexes had the ability to reduce the viability of melanoma cells by 35–40%, while exhibiting no cytotox- icity against the normal human fibroblast (BJ) cell line, which is an extremely desirable feature. Thus, it may be concluded that Fe3O4–montmorillonite and Fe3O4–bentonite complexes hold promise for use in the management of infected wounds and wounds after melanoma excision. |
