Harnessing Bacterial Lipid Coatings on Gold Nanoparticles for Enhanced Cell Adhesion Applications
Artykuł w czasopiśmie
MNiSW
20
Lista 2024
| Status: | |
| Autorzy: | Gharehgozlo Soroosh, Polash Shakil Ahmed, Mirihana Kalpani A., Matusiak Jakub, Giles Lauren, Vaillant Pierre, Kodakkat Shreehari, Ch'ng Serena, Penman Rowan, Cheeseman Samuel, Alexandrou Lydon, Vongsvivut Jitraporn, Clulow Andrew J., Christofferson Andrew J., Ramsland Paul A., Bryant Saffron J., Elbourne Aaron |
| Dyscypliny: | |
| Aby zobaczyć szczegóły należy się zalogować. | |
| Rok wydania: | 2026 |
| Wersja dokumentu: | Elektroniczna |
| Język: | angielski |
| Numer czasopisma: | 2 |
| Wolumen/Tom: | 6 |
| Numer artykułu: | e202500584 |
| Strony: | 1 - 17 |
| Efekt badań statutowych | NIE |
| Materiał konferencyjny: | NIE |
| Publikacja OA: | TAK |
| Licencja: | |
| Sposób udostępnienia: | Witryna wydawcy |
| Wersja tekstu: | Ostateczna wersja opublikowana |
| Czas opublikowania: | W momencie opublikowania |
| Data opublikowania w OA: | 17 lutego 2026 |
| Abstrakty: | angielski |
| Antimicrobial resistance (AMR) is a global health challenge responsible for millions of deaths annually. Hence, there is an urgent need for improved strategies to combat AMR. Nanoparticle (NP)-based drug delivery has shown promise for enhancing the efficacy of conventional antibiotic treatments. Moreover, lipid functionalization of NP surfaces can enhance drug loading, colloidal stability, and specificity. Cell membrane vesicles as the outer shell coating for NPs provokes a unique interaction between fabricated NPs and their respective parent bacteria. Despite numerous studies having investigated the use of bacterial extracellular vesicle coatings for drug delivery, to the best of our knowledge, the potential of isolated bacterial membrane lipids has not yet been explored. This study investigates how particle-cell adhesion changes when gold NPs (AuNPs) coated with bacterial membrane lipids are re-introduced to their original parent cells. Hence, bacterial lipid coated AuNPs (BLC-AuNPs) were constructed using AuNPs in conjunction with membrane lipids harvested from Escherichia coli. Compared with bare AuNPs, BLC-AuNPs showed significant increase in particle-cell adhesion upon re-exposure confirmed by confocal and electron microscopy. Lipid coating also improved particle distribution and surface coverage on bacterial cells. These findings suggest that bacterial membrane lipid coating provides an effective biomimetic strategy, enhancing drug deliveryto drug resistant pathogens |
