Distribution of Toxic and Essential Elements in Autopsy Organs of Subjects Living in South-Eastern Poland
Artykuł w czasopiśmie
MNiSW
0
brak dyscyplin
| Status: | |
| Autorzy: | Flieger Wojciech, Niedzielski Przemysław, Flieger Michał, Wojciechowska Zofia, Proch Aleksandra, Proch Jędrzej, Forma Alicja, Torbicz Andrzej, Majerek Dariusz, Teresiński Grzegorz, Baj Jacek, Dzierżyński Eliasz, Flieger Jolanta |
| Dyscypliny: | |
| Aby zobaczyć szczegóły należy się zalogować. | |
| Rok wydania: | 2026 |
| Wersja dokumentu: | Elektroniczna |
| Język: | angielski |
| Numer czasopisma: | 6 |
| Wolumen/Tom: | 27 |
| Numer artykułu: | 2585 |
| Strony: | 1 - 29 |
| Impact Factor: | 4,9 |
| Efekt badań statutowych | NIE |
| Materiał konferencyjny: | NIE |
| Publikacja OA: | TAK |
| Licencja: | |
| Sposób udostępnienia: | Witryna wydawcy |
| Wersja tekstu: | Ostateczna wersja opublikowana |
| Czas opublikowania: | W momencie opublikowania |
| Data opublikowania w OA: | 11 marca 2026 |
| Abstrakty: | angielski |
| Chronic exposure to heavy metals poses significant health risks. This study analyzed the concentrations of toxic (Cr, Pb, Cd, Ni) and essential (Cu, Zn, Se, Mn) elements in autopsy samples (the frontal pole area of the brain, the 6th intercostal space of the liver, and lungs (average of left and right lung samples) from 45 residents of South-Eastern Poland using ICP-MS. The aim was to determine the average body burden and organ-specific accumulation in a moderately industrialized region. HDBSCAN clustering revealed highly homogeneous elemental profiles, suggesting a unifying influence of local environmental factors. The liver acted as a metabolic hub, showing preferential sequestration (p < 0.0001) of essential elements (Zn, Se, Mn, Cu) regulated by homeostatic mechanisms. Toxic metals exhibited ‘metabolic trap’ patterns, particularly Cd and Pb in the liver and Cr in the lungs, due to their long biological half-lives. Strong positive correlations (Se–Zn, Se–Cu) indicated integrated antioxidant responses, while toxic pairs (Cr–Ni, Pb–Cd) suggested shared exposure pathways and molecular mimicry via transporters such as DMT1. Results confirmed long-term bioaccumulation, with toxic elements in the brain remaining below 0.25 µg/g. In the lungs, the accumulation hierarchy (Pb > Mn > Cd > Cr) reflected inhalation exposure. These findings emphasize the role of organ-specific sequestration in assessing long-term environmental exposure |
