Chitosan-coated zeolites as a promising platform for sodium risedronate adsorption
Artykuł w czasopiśmie
MNiSW
140
Lista 2024
| Status: | |
| Autorzy: | Matusiak Jakub, Panek Rafał, Kazimierczak Paulina, Wójcik Alicja, Kazemian Hossein, Przekora Agata, Franus Wojciech |
| Dyscypliny: | |
| Aby zobaczyć szczegóły należy się zalogować. | |
| Rok wydania: | 2026 |
| Wersja dokumentu: | Drukowana | Elektroniczna |
| Język: | angielski |
| Wolumen/Tom: | 268 |
| Numer artykułu: | 116560 |
| Strony: | 1 - 17 |
| Web of Science® Times Cited: | 0 |
| Scopus® Cytowania: | 0 |
| Bazy: | Web of Science | Scopus |
| Efekt badań statutowych | NIE |
| Finansowanie: | The authors gratefully acknowledge support from the National Science Centre, Poland (grant no. UMO-2021/43/B/NZ7/00447). |
| Materiał konferencyjny: | NIE |
| Publikacja OA: | TAK |
| Licencja: | |
| Sposób udostępnienia: | Otwarte czasopismo |
| Wersja tekstu: | Ostateczna wersja opublikowana |
| Czas opublikowania: | W momencie opublikowania |
| Data opublikowania w OA: | 8 lipca 2026 |
| Abstrakty: | angielski |
| In this work, we report the synthesis and evaluation of chitosan-coated zeolites as adsorptive platforms for the delivery of sodium risedronate. Chitosan was selected due to its pH-responsive behaviour and inherent biocompatibility, serving both as a surface functional layer and as a regulator of drug–surface interactions. Comprehensive physicochemical characterisation (XRD, XRF, SEM/EDS, BET, zeta potential) confirmed successful surface functionalisation without significant loss of zeolite crystallinity. Cytotoxicity studies demonstrated that native zeolites significantly reduced cell viability, whereas chitosan-modified materials remained non-cytotoxic, confirming the beneficial role of polymer functionalisation. Adsorption studies revealed heterogeneous and multilayer adsorption behaviour, with calcium-exchanged chitosan-modified zeolites exhibiting the highest adsorption performance under optimised conditions. Mechanistic analysis indicated that adsorption was primarily governed by weak non-covalent interactions and was strongly influenced by pH-dependent electrostatic attraction between deprotonated phosphonate groups of risedronate and protonated amine groups of chitosan. Additional stability studies demonstrated partial framework-related ion release under acidic conditions while preserving the overall crystalline structure of the materials. Overall, the results highlight the potential of chitosan-functionalised zeolites as multifunctional platforms for pH-responsive bisphosphonate adsorption and future biomedical delivery applications. |
