Baza Publikacji Pracowników Politechniki Lubelskiej

Status:
Autorzy:	Krukow Paweł, Jonak Kamil, Karpiński Robert, Karakuła-Juchnowicz Hanna
Dyscypliny:
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Rok wydania:	2019
Wersja dokumentu:	Elektroniczna
Język:	angielski
Numer czasopisma:	9
Numer artykułu:	9594
Strony:	1 - 13
Impact Factor:	3,998
Web of Science® Times Cited:	25
Scopus® Cytowania:	29
Bazy:	Web of Science \| Scopus
Efekt badań statutowych	TAK
Materiał konferencyjny:	NIE
Publikacja OA:	TAK
Licencja:
Sposób udostępnienia:	Witryna wydawcy
Wersja tekstu:	Ostateczna wersja opublikowana
Czas opublikowania:	W momencie opublikowania
Data opublikowania w OA:	3 lipca 2019
Abstrakty:	angielski
	Introducing the Minimum Spanning Tree (MST) algorithms to neural networks science eliminated the problem of arbitrary setting of the threshold for connectivity strength. Despite these advantages, MST has been rarely used to study network abnormalities in schizophrenia. An MST graph mapping a network structure is its simplification, therefore, it is important to verify whether the reconfigured network is significantly related to the behavioural dimensions of the clinical picture of schizophrenia. 35 first-episode schizophrenia patients and 35 matched healthy controls underwent an assessment of information processing speed, cognitive inter-trial variability modelled with ex-Gaussian distributional analysis of reaction times and resting-state EEG recordings to obtain frequency-specific functional connectivity matrices from which MST graphs were computed. The patients’ network had a more random structure and star-like arrangement with overloaded hubs positioned more posteriorly than it was in the case of the control group. Deficient processing speed in the group of patients was predicted by increased maximal betweenness centrality in beta and gamma bands, while decreased consistency in cognitive processing was predicted by the betweenness centrality of posterior nodes in the gamma band, together with duration of illness. The betweenness centrality of posterior nodes in the gamma band was also significantly correlated with positive psychotic symptoms in the clinical group.

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Abnormalities in hubs location and nodes centrality predict cognitive slowing and increased performance variability in first-episode schizophrenia patients

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