Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification
Artykuł w czasopiśmie
MNiSW
100
Lista 2021
Status: | |
Autorzy: | Muth Daniel Rudolf , Toro Mario Damiano, Bajka Anahita, Jonak Kamil, Rieder Roman , Kohler Myrtha Magdalena , Gunzinger Jeanne Martine, Souied Eric H., Engelbert Michael, Freund K. Bailey , Zweifel Sandrine Anne |
Dyscypliny: | |
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Rok wydania: | 2022 |
Wersja dokumentu: | Elektroniczna |
Język: | angielski |
Numer czasopisma: | 10 |
Wolumen/Tom: | 10 |
Numer artykułu: | 2370 |
Strony: | 1 - 9 |
Impact Factor: | 4,7 |
Web of Science® Times Cited: | 5 |
Scopus® Cytowania: | 5 |
Bazy: | Web of Science | Scopus |
Efekt badań statutowych | NIE |
Finansowanie: | This research received no external funding. |
Materiał konferencyjny: | NIE |
Publikacja OA: | TAK |
Licencja: | |
Sposób udostępnienia: | Witryna wydawcy |
Wersja tekstu: | Ostateczna wersja opublikowana |
Czas opublikowania: | W momencie opublikowania |
Data opublikowania w OA: | 22 września 2022 |
Abstrakty: | angielski |
Background To investigate associations and predictive factors between macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naïve neovascular age-related macular degeneration (AMD). Methods: Multimodal imaging was retrospectively reviewed for druse type (soft drusen, subretinal drusenoid deposits (SDDs) or mixed) and MNV type (MNV 1, MNV 2, MNV 1/2 or MNV 3). The Consensus on Neovascular AMD Nomenclature (CONAN) classification was used for characterizing MNV at baseline. Results: One eye of each eligible patient was included (n = 191). Patients with predominant SDDs had an increased adjusted odds ratio (aOR) for MNV 2 (23.4453, p = 0.0025) and any type of MNV 3 (8.7374, p < 0.0001). Patients with MNV 1/2 had an aOR for predominant SDDs (0.3284, p = 0.0084). Patients with MNV1 showed an aOR for SDDs (0.0357, p < 0.0001). Eyes with SDDs only without other drusen types showed an aOR for MNV 2 (9.2945, p < 0.0001). Conclusions: SDDs represent a common phenotypic characteristic in AMD eyes with treatment-naïve MNV. The aOR for eyes with predominant SDDs to develop MNV 2 and MNV 3 was much higher, possibly due to their location in the subretinal space. The predominant druse type may help to predict which type of MNV will develop during the course of AMD. |