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Publikacje Pracowników Politechniki Lubelskiej

MNiSW
200
Lista 2023
Status:
Autorzy: Diedkova Kateryna, Pohrebniak Oleksandr, Kyrylenko Sergiy, Smyrnova Kateryna V., Buranich Vladimir V., Horodek Paweł, Żukowski Paweł, Kołtunowicz Tomasz, Gałaszkiewicz Piotr, Makashina Kristina, Bondariev Vitalii, Sahul Martin, Čaplovičová Maria, Husak Yevheniia, Simka Wojciech, Korniienko Viktoriia, Stolarczyk Agnieszka, Blacha-Grzechnik Agata, Balitskyi Vitalii, Zahorodna Veronika, Baginskiy Ivan, Riekstina Una, Gogotsi Oleksiy, Gogotsi Yury, Pogorielov Maksym
Dyscypliny:
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Rok wydania: 2023
Wersja dokumentu: Drukowana | Elektroniczna
Język: angielski
Numer czasopisma: 11
Wolumen/Tom: 15
Strony: 14033 - 14047
Impact Factor: 8,3
Web of Science® Times Cited: 34
Scopus® Cytowania: 36
Bazy: Web of Science | Scopus
Efekt badań statutowych NIE
Finansowanie: Supported by the Ministry of Education and Science of Ukraine (grants 0120U101972 and 0122U000784), H2020 Marie Skłodowska-Curie Actions (NanoSurf 777926, CanBioSe 778157, NANO2DAY 77810, SALSETH 872370), Horizon Europe project MX-MAP (#101086184), Erasmus+ Jean Monnet Chair project CircuMed #101085451; also received support from the Ministry of Education and Science (Poland) for the Lublin University of Technology for activities in Automation, Electronics, and Electrical Engineering (grants FD-20/EE-2/701, FD-20/EE-2/703, and FD-20/EE-2/709).
Materiał konferencyjny: NIE
Publikacja OA: TAK
Licencja:
Sposób udostępnienia: Witryna wydawcy
Wersja tekstu: Ostateczna wersja opublikowana
Czas opublikowania: W momencie opublikowania
Data opublikowania w OA: 9 marca 2023
Abstrakty: angielski
New conductive materials for tissue engineering are needed for the development of regenerative strategies for nervous, muscular, and heart tissues. Polycaprolactone (PCL) is used to obtain biocompatible and biodegradable nanofiber scaffolds by electrospinning. MXenes, a large class of biocompatible 2D nanomaterials, can make polymer scaffolds conductive and hydrophilic. However, an understanding of how their physical properties affect potential biomedical applications is still lacking. We immobilized Ti3C2Tx MXene in several layers on the electrospun PCL membranes and used positron annihilation analysis combined with other techniques to elucidate the defect structure and porosity of nanofiber scaffolds. The polymer base was characterized by the presence of nanopores. The MXene surface layers had abundant vacancies at temperatures of 305–355 K, and a voltage resonance at 8 × 104 Hz with the relaxation time of 6.5 × 106 s was found in the 20–355 K temperature interval. The appearance of a long-lived component of the positron lifetime was observed, which was dependent on the annealing temperature. The study of conductivity of the composite scaffolds in a wide temperature range, including its inductive and capacity components, showed the possibility of the use of MXene-coated PCL membranes as conductive biomaterials. The electronic structure of MXene and the defects formed in its layers were correlated with the biological properties of the scaffolds in vitro and in bacterial adhesion tests. Double and triple MXene coatings formed an appropriate environment for cell attachment and proliferation with mild antibacterial effects. A combination of structural, chemical, electrical, and biological properties of the PCL–MXene composite demonstrated its advantage over the existing conductive scaffolds for tissue engineering.